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Transpl Infect Dis. 2016 Apr;18(2):288-92. doi: 10.1111/tid.12516.

Guillain-Barré syndrome associated with resistant cytomegalovirus infection after face transplantation.

Author information

1
Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
2
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
3
Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
4
Division of Plastic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
5
Division of Neuromuscular Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
6
Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Abstract

A 39-year-old male, who received a facial allograft (cytomegalovirus [CMV] donor-seropositive, recipient-seronegative), developed multidrug-resistant CMV infection despite valganciclovir prophylaxis (900 mg/day) 6 months post transplantation. Lower extremity weakness with upper and lower extremity paresthesias developed progressively 11 months post transplantation, coinciding with immune control of CMV. An axonal form of Guillain-Barré syndrome was diagnosed, based on electrophysiological evidence of a generalized, non-length-dependent, sensorimotor axonal polyneuropathy. Treatment with intravenous immunoglobulin led to complete recovery without recurrence after 6 months.

KEYWORDS:

Guillain-Barré syndrome; cytomegalovirus; face transplantation; peripheral neuropathy; vascularized composite allotransplantation

PMID:
26910286
DOI:
10.1111/tid.12516
[Indexed for MEDLINE]

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