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Arch Endocrinol Metab. 2016 Feb;60(1):76-8. doi: 10.1590/2359-3997000000147.

Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast.

Author information

1
Iaso General Hospital, Athens, Greece.
2
Euromedica High Technology S.A, Athens, Greece.
3
Aretaieion University Hospital, Athens Medical School, Athens, Greece.
4
First Department of Pediatrics, School of Medicine, University of Athens, Athens, Greece.

Abstract

OBJECTIVE:

In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast.

SUBJECTS AND METHODS:

We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 ± 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 ± 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05.

RESULTS:

In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state.

CONCLUSION:

These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes.

PMID:
26909486
DOI:
10.1590/2359-3997000000147
[Indexed for MEDLINE]
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