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Nanomedicine (Lond). 2015 Nov;10(22):3359-71.

Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains.

Abstract

AIM:

To explore the potential of de novo designed cyclic lipopeptides and its linear counterparts as antibacterial agents.

MATERIALS & METHODS:

The lipopeptides were synthesized via solid-phase peptide synthesis and the cyclization was achieved by using succinic acid linker. The antimicrobial activities of the lipopeptides were evaluated in vitro against a variety selection of Gram-negative and Gram-positive bacteria including clinical isolates of multidrug-resistant strains.

RESULTS:

The synthesized lipopeptides were able to self-assemble into nanoparticles in an aqueous environment, with three exhibiting potent antibacterial activity against Gram-positive bacteria, including clinically relevant multidrug-resistant bacteria.

CONCLUSION:

The lead compounds have the potential to be developed as new antibacterials that are effective against Gram-positive bacteria, including multidrug-resistant isolates.

PMID:
26909416
[Indexed for MEDLINE]

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