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Avicenna J Phytomed. 2015 Jul-Aug;5(4):341-54.

Effect of Malva sylvestris cream on burn injury and wounds in rats.

Author information

1
Traditional and Complementary Medicine Research Center, Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
2
Traditional and Complementary Medicine Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
3
Traditional and Complementary Medicine Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
4
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
5
Department of Laboratory Medicine, Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.

Abstract

OBJECTIVES:

Burn injury is one of the most health-threatening problems in the world. Malva sylvestris (M. sylvestris) flowers have a high mucilage content and are used as a remedy for cut wound and dermal infected wounds in Iranian folklore Medicine. The purpose of this study was to investigate the effect of M. sylvestris cream on the second degree burn injury in rats.

MATERIALS AND METHODS:

Five groups of 10 rats per group were burned with hot metal plate. Animals were administrated divided as control, normal saline, standard silver sulfadiazine 1% (SSD), 5% M. sylvestris, and 10% M. sylvestris into separate groups. Wound area, percentage of wound contraction, and histological and bacteriological assessments were evaluated.

RESULTS:

Wound sizes were not significantly different among groups on 1(st) and 3(rd) days after burn injury, while they were significantly different among groups after 7(th) day post-burn injury. The average areas of wounds on the 15(th) day were 7.5±2.9, 6.7±2, 10.5±1.6, 4.7±2, and 4.5±2 cm(2) for base cream, normal saline, SSD, 5% M. sylvestris, and 10% M. sylvestris, respectively. The results of histology exhibited well-formed horizontally-oriented collagen fibers in MS topical treatment groups. Microorganisms existed in the SSD group were most probably Staphilococcus epidermitis and for NS group were staphylococcus saprophiteccus.

CONCLUSION:

M. sylvestris cream improved histological changes of tissue components in the process of healing when compared with SSD cream. Therefore, it can be used as a topical treatment agent for burn wound.

KEYWORDS:

Burns; Malva sylvestris; Rats; Silver sulfadiazine; Wound healing

PMID:
26909337
PMCID:
PMC4587603

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