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Clin Infect Dis. 2016 May 1;62(9):1136-1138. doi: 10.1093/cid/ciw060. Epub 2016 Feb 11.

Norovirus Infections Occur in B-Cell-Deficient Patients.

Author information

1
Microbiology Virology & Infection Control, Great Ormond Street Hospital for Children National Health Service (NHS) Foundation Trust.
2
National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London.
3
Immunology Department, Great Ormond Street Hospital for Children NHS Foundation Trust.
4
Infection and Immunity, University College London, United Kingdom.

Abstract

Norovirus incidence was compared between severe combined immunodeficiency children with (n = 10) and without (n = 8) B cells. 60% of B+ and 63% of B- patients developed norovirus infections therefore norovirus replication in B lymphocytes is not essential for infection.

KEYWORDS:

B cells; SCID; in vivo; norovirus

Comment in

PMID:
26908782
DOI:
10.1093/cid/ciw060
[Indexed for MEDLINE]

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