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J Infect Dis. 2016 Mar 1;213(5):694-702. doi: 10.1093/infdis/jiv326. Epub 2015 Jun 8.

Transfusion-Transmitted Dengue and Associated Clinical Symptoms During the 2012 Epidemic in Brazil.

Author information

1
Departamento de Moléstias Infecciosas e Parasitárias, Instituto de Medicina Tropical, Universidade de São Paulo.
2
Faculdade de Ciências Médicas-UPE/Fundação Hemope, Recife.
3
Fundação Hemorio, Rio de Janeiro, Brazil.
4
RTI International, Rockville, Maryland.
5
Universidade Federal de São Joao del Rey, Divinopolis, Brazil.
6
Hologic, San Diego.
7
Blood Systems Research Institute, San Francisco, California.
8
Blood Systems Research Institute, San Francisco, California University of British Columbia, Vancouver, Canada.
9
Blood Systems Research Institute, San Francisco, California Department of Laboratory Medicine, University of California-San Francisco.

Abstract

BACKGROUND:

A linked donor-recipient study was conducted during epidemics in 2 cities in Brazil to investigate transfusion-transmitted (TT) dengue virus (DENV) by DENV RNA-positive donations.

METHODS:

During February-June 2012, samples were collected from donors and recipients and retrospectively tested for DENV RNA by transcription-mediated amplification. Recipient chart review, using a case (DENV positive)-control (DENV negative and not known to be exposed) design, was conducted to assess symptoms.

RESULTS:

Of 39 134 recruited blood donors, DENV-4 viremia was confirmed in 0.51% of donations from subjects in Rio de Janeiro and 0.80% of subjects in Recife. Overall, 42 DENV RNA-positive units were transfused into 35 recipients. Of these, 16 RNA-positive units transfused into 16 susceptible recipients were identified as informative: 5 cases were considered probable TT cases, 1 possible TT case, and 10 nontransmissions. The TT rate was 37.5% (95% confidence interval [CI], 15.2%-64.6%), significantly higher than the viremia rate of 0.93% (95% CI, .11%-3.34%) in nonexposed recipients (P < .0001). Chart review did not find significant differences between cases and controls in symptoms or mortality.

CONCLUSIONS:

During a large epidemic of DENV-4 infection in Brazil, >0.5% of donations were RNA positive, and approximately one third of components resulted in TT. However, no significant clinical differences were evident between RNA-positive and RNA-negative recipients.

KEYWORDS:

NAT; clinical symptoms; dengue; transfusion-transmission

Comment in

PMID:
26908780
PMCID:
PMC4747611
[Available on 2017-03-01]
DOI:
10.1093/infdis/jiv326
[Indexed for MEDLINE]
Free PMC Article

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