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Clin Trials. 2016 Jun;13(3):358-66. doi: 10.1177/1740774515626362. Epub 2016 Feb 17.

Efficiencies of platform clinical trials: A vision of the future.

Author information

1
Berry Consultants, Austin, TX, USA Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA ben@berryconsultants.com.
2
Berry Consultants, Austin, TX, USA Adjunct faculty, University of Kansas Medical Center, Department of Biostatistics, KS, USA.

Abstract

BACKGROUND:

A "platform trial" is a clinical trial with a single master protocol in which multiple treatments are evaluated simultaneously. Adaptive platform designs offer flexible features such as dropping treatments for futility, declaring one or more treatments superior, or adding new treatments to be tested during the course of a trial.

METHODS:

A simulation study explores the efficiencies of various platform trial designs relative to a traditional two-arm strategy.

RESULTS:

Platform trials can find beneficial treatments with fewer patients, fewer patient failures, less time, and with greater probability of success than a traditional two-arm strategy.

CONCLUSION:

In an era of personalized medicine, platform trials provide the innovation needed to efficiently evaluate modern treatments.

KEYWORDS:

Bayesian; Platform trial; adaptive; clinical trial design; master protocol; multi-arm

PMID:
26908536
DOI:
10.1177/1740774515626362
[Indexed for MEDLINE]

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