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Nat Rev Mol Cell Biol. 2016 Mar;17(3):194-200. doi: 10.1038/nrm.2016.10.

Pluripotent stem cells progressing to the clinic.

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Monash University and Hudson Institute for Medical Research, 27-31 Right Street, Clayton, Victoria 3168, Australia.
California Institute for Regenerative Medicine (CIRM), 1999 Harrison Street, Suite 1650, Oakland, 94612, USA.
Accendo, 2839 Pierce Street #1, San Francisco, California 94123, USA.


Basic experimental stem cell research has opened up the possibility of many diverse clinical applications; however, translation to clinical trials has been restricted to only a few diseases. To broaden this clinical scope, pluripotent stem cell derivatives provide a uniquely scalable source of functional differentiated cells that can potentially repair damaged or diseased tissues to treat a wide spectrum of diseases and injuries. However, gathering sound data on their distribution, longevity, function and mechanisms of action in host tissues is imperative to realizing their clinical benefit. The large-scale availability of treatments involving pluripotent stem cells remains some years away, because of the long and demanding regulatory pathway that is needed to ensure their safety.

[Indexed for MEDLINE]

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