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Rev Stomatol Chir Maxillofac Chir Orale. 2016 Jun;117(3):142-6. doi: 10.1016/j.revsto.2016.01.007. Epub 2016 Feb 19.

[Central giant cell granuloma in children: Presentation of different therapeutic options].

[Article in French]

Author information

1
Service de chirurgie maxillo-faciale, stomatologie et chirurgie plastique de la face, université d'Auvergne, NHE, CHU de Clermont-Ferrand, 1, place Lucie-Aubrac, 63003 Clermont-Ferrand, France; UMR Inserm/UdA, U1107, neuro-dol, trigeminal pain and migraine, faculté de chirurgie dentaire, BP 10448, 63000 Clermont-Ferrand, France. Electronic address: nphamdang@chu-clermontferrand.fr.
2
Service de chirurgie maxillo-faciale, stomatologie et chirurgie plastique de la face, université d'Auvergne, NHE, CHU de Clermont-Ferrand, 1, place Lucie-Aubrac, 63003 Clermont-Ferrand, France.
3
Service d'odontologie, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand, France.
4
Service de chirurgie maxillo-faciale, stomatologie et chirurgie plastique de la face, université d'Auvergne, NHE, CHU de Clermont-Ferrand, 1, place Lucie-Aubrac, 63003 Clermont-Ferrand, France; UMR Inserm/UdA, U1107, neuro-dol, trigeminal pain and migraine, faculté de chirurgie dentaire, BP 10448, 63000 Clermont-Ferrand, France; Faculté de médecine, université d'Auvergne, Clermont université, BP 10448, 63000 Clermont-Ferrand, France.

Abstract

Central giant cell granuloma (CGCG) is a benign tumor that may be subdivided in a non-aggressive form and an aggressive form. In aggressive forms, tumor size and high recurrence risk need large surgical resections. In order to minimize surgical morbidity, especially in children, medical treatments acting on the tumor proliferation are currently being assessed: steroids (triamcinolone), anti-osteoclastic drugs (calcitonine, alendronate, denosumab), anti-angiogenic drugs (interferon α). However to date, there is no evidence for any superiority of medical over surgical treatment. Complete response is rarely obtained and additional surgery is often necessary to remove the tumor in case of tumor progression, to remove a remnant or to remodel bone. Moreover, these drugs have frequent local or systemic side effects such as osteonecrosis and growth deficiencies.

KEYWORDS:

Alendronate; Calcitonine; Corticothérapie; Denosumab; Granuloma giant cell; Granulome central à cellules géantes; Interferon; Steroids

PMID:
26907517
DOI:
10.1016/j.revsto.2016.01.007
[Indexed for MEDLINE]

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