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Nat Genet. 2016 Mar;48(3):226-7. doi: 10.1038/ng.3516.

Enabling direct fate conversion with network biology.

Author information

1
Institute for Cell Engineering and in the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract

Current efforts in cellular disease modeling and regenerative medicine are limited by the paucity of cell types that can be generated in the laboratory. A new study introduces a computational framework, Mogrify, that uses network biology to predict combinations of transcription factors necessary for direct conversion between human cell types to ameliorate this issue.

PMID:
26906680
DOI:
10.1038/ng.3516
[Indexed for MEDLINE]

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