Format

Send to

Choose Destination
J Clin Rheumatol. 2016 Mar;22(2):71-4. doi: 10.1097/RHU.0000000000000359.

Bone Mineral Density in Patients With Rheumatoid Arthritis and 4-Year Follow-up Results.

Author information

1
From the *First Affiliated Hospital of Shantou University Medical College; †Shantou University Medical College; and ‡Department of Rheumatology, First Affiliated Hospital of Shantou University Medical College, Guangdong Province, China.

Abstract

BACKGROUND:

Osteoporosis is a common complication in patients with rheumatoid arthritis (RA). The change of bone mineral density (BMD) in patients with RA is slow, and little data are known about the long-term change of BMD.

OBJECTIVES:

This study aimed to determine the frequency of osteoporosis and the long-term change on BMD in a cohort of Chinese patients with RA routinely receiving calcium and vitamin D supplementation.

METHODS:

A total of 304 consecutive patients with RA were recruited. Bone mineral density measurements of the forearm, lumbar spine, and total hip were performed by dual-energy x-ray absorptiometry and compared with 200 age- and sex-matched healthy controls. Risk factors were analyzed by logistic regression models.

RESULTS:

The prevalence of osteoporosis at all measured sites in patients with RA was statistically significantly higher than in healthy controls. A total of 107 patients of the cohort had a mean of 4 years of follow-up. More patients with BMD decrease were found without calcium and vitamin D use compared with those who continuously took calcium and vitamin D (64.3% vs 19.8% at the forearm and 28.6% vs 16.1% at the total hip, respectively). Only the use of calcium and vitamin D supplementation was associated with a decreased risk of BMD decrease both at the forearm and at the total hip.

CONCLUSIONS:

Osteoporosis is common in Chinese patients with RA. Routine use of calcium and vitamin D supplementation decreased the risk of BMD decrease and should be recommended for all patients with RA.

PMID:
26906298
DOI:
10.1097/RHU.0000000000000359
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center