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Front Microbiol. 2016 Feb 11;7:144. doi: 10.3389/fmicb.2016.00144. eCollection 2016.

Extraintestinal Infections Caused by Non-toxigenic Vibrio cholerae non-O1/non-O139.

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Department of Bacteriology, National Institute of Cholera and Enteric Diseases Kolkata, India.
Manipal Hospital Bangalore, India.
Tata Medical Center Kolkata, India.
Sri Ramachandra Medical Centre Chennai, India.
Metropolis Healthcare Ltd-Global Hospital Mumbai, India.
Collaborative Research Centre of Okayama University for Infectious Diseases in India, National Institute of Cholera and Enteric Diseases Kolkata, India.
Translational Health Science and Technology Institute, NCR Biotech Science Cluster Faridabad, India.


Vibrio cholerae is an aerobic, sucrose fermentative Gram-negative bacterium that generally prevails in the environment. Pathogenic V. cholerae is well-known as causative agent of acute diarrhea. Apart from enteric infections, V. cholerae may also cause other diseases. However, their role in causing extraintestinal infections is not fully known as it needs proper identification and evaluation. Four cases of extraintestinal infections due to V. cholerae non-O1/non-O139 have been investigated. The isolates were screened for phenotypic and genetic characteristics with reference to their major virulence genes. Serologically distinct isolates harbored rtx, msh, and hly but lacked enteric toxin encoding genes that are generally present in toxigenic V. cholerae. Timely detection of this organism can prevent fatalities in hospital settings. The underlying virulence potential of V. cholerae needs appropriate testing and intervention.


UTI; V. cholerae; hematuria; ompW-PCR; septicaemia; serogroup identification

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