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Mult Scler. 2016 Dec;22(14):1812-1820. Epub 2016 Feb 22.

Impaired retinal microcirculation in multiple sclerosis.

Author information

1
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA/Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA h.jiang@med.miami.edu.
2
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
3
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA/Department of Ophthalmology, The Second Xiangya Hospital, Central-South University, Changsha, China.
4
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
5
Statistic Division, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Abstract

BACKGROUND:

The transparent ocular structure enables quantitative analysis of microvasculature of retina, a neuronal tissue affected by multiple sclerosis (MS).

OBJECTIVE:

The aim of this study was to determine whether the retinal blood flow velocity and flow volume at the macula are impaired in patients with relapsing remitting multiple sclerosis (RRMS).

METHODS:

A total of 17 RRMS patients and 17 age- and gender-matched healthy subjects were assessed. A retinal function imager was used to measure the blood flow velocity of retinal arterioles and venules and to calculate the total perifoveal blood flow volume.

RESULTS:

The blood flow velocities of the retinal arterioles (3.34 ± 0.89 mm/s) and venules (2.61 ± 0.6 mm/s) were significantly lower in MS patients than normal subjects (arteriole: 4.10 ± 0.87 mm/s; venule: 3.22 ± 0.65 mm/s, both p = 0.01). In addition, the total perifoveal blood flow volume in arterioles (3.74 ± 1.64 nL/s) and venules (3.81 ± 1.60 nL/s) were significantly lower in MS patients than in normal subjects (arteriole: 4.87 ± 1.41 nL/s, p = 0.02; venule: 4.71 ± 1.64 nL/s, p = 0.04).

CONCLUSION:

The impaired retinal microcirculation in RRMS patients indicates microvascular dysfunction in MS.

KEYWORDS:

Multiple sclerosis; blood flow velocity; blood flow volume; retinal function imager; retinal microcirculation; retinal nerve fiber layer

PMID:
26903007
PMCID:
PMC4993688
DOI:
10.1177/1352458516631035
[Indexed for MEDLINE]
Free PMC Article

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