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Bone Marrow Transplant. 2016 Jun;51(6):778-85. doi: 10.1038/bmt.2016.18. Epub 2016 Feb 22.

Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey.

Author information

1
The Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital Basel, Basel, Switzerland.
2
Department of Hematology-Oncology, University Hospital, Leipzig, Germany.
3
The Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), Royal Melbourne Hospital, Parkville, VIC, Australia.
4
Institute for Operations Research and Computational Finances, University of St Gallen, St Gallen, Switzerland.
5
The Eastern Mediterranean Blood and Marrow Transplant Group (EMBMT), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
6
Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
7
The Latin American Blood and Marrow Transplant Group (LABMT), Instituto Nacional de Cancer, Rio de Janeiro, Brazil.
8
National Marrow Donor Program, Minneapolis, MN, USA.
9
Medical University of Graz, Division of Hematology, Graz, Austria.
10
The Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI, USA.
11
The Asian Pacific Blood and Marrow Transplant Group (APBMT) Data Centre, Aichi Medical University, School of Medicine, Aichi, Japan.
12
The Canadian Blood and Marrow Transplant Group (CBMTG), Princess Margaret Hospital, Toronto, ON, Canada.
13
The European Blood and Marrow Transplant Group (EBMT), Hôpital St Antoine, St Antoine, Paris.
14
The African Blood and Marrow Transplant Group (AFBMT), Johannesburg, South Africa.
15
The World Health Organization WHO, Geneva, Switzerland.
16
Aichi Medical University, School of Medicine, Aichi, Japan.
17
Department of Hematology, Hammersmith Hospital, London, UK.
18
Department of Pediatric, Hospital Samaritano, Sao Paulo, Brazil.

Abstract

Data on 68 146 hematopoietic stem cell transplants (HSCTs) (53% autologous and 47% allogeneic) gathered by 1566 teams from 77 countries and reported through their regional transplant organizations were analyzed by main indication, donor type and stem cell source for the year 2012. With transplant rates ranging from 0.1 to 1001 per 10 million inhabitants, more HSCTs were registered from unrelated 16 433 donors than related 15 493 donors. Grafts were collected from peripheral blood (66%), bone marrow (24%; mainly non-malignant disorders) and cord blood (10%). Compared with 2006, an increase of 46% total (57% allogeneic and 38% autologous) was observed. Growth was due to an increase in reporting teams (18%) and median transplant activity/team (from 38 to 48 HSCTs/team). An increase of 167% was noted in mismatched/haploidentical family HSCT. A Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis revealed the global perspective of WBMT to be its major strength and identified potential to be the key professional body for patients and authorities. The limited data collection remains its major weakness and threat. In conclusion, global HSCT grows over the years without plateauing (allogeneic>autologous) and at different rates in the four World Health Organization regions. Major increases were observed in allogeneic, haploidentical HSCT and, to a lesser extent, in cord blood transplantation.

PMID:
26901703
PMCID:
PMC4889523
DOI:
10.1038/bmt.2016.18
[Indexed for MEDLINE]
Free PMC Article

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