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Curr Opin Cell Biol. 2016 Feb;38:38-44. doi: 10.1016/j.ceb.2016.02.004. Epub 2016 Feb 20.

Adder and a coarse-grained approach to cell size homeostasis in bacteria.

Author information

1
UCSD Physics and Molecular Biology, 9500 Gilman Dr., La Jolla, CA 92093, United States.
2
UCSD Physics and Molecular Biology, 9500 Gilman Dr., La Jolla, CA 92093, United States. Electronic address: suckjoon.jun@gmail.com.

Abstract

Cell size control and homeostasis is a long-standing subject in biology. Recent experimental work provides extensive evidence for a simple, quantitative size homeostasis principle coined adder (as opposed to sizer or timer). The adder principle provides unexpected insights into how bacteria maintain their size without employing a feedback mechanism. We review the genesis of adder and recent cell size homeostasis study on evolutionarily divergent bacterial organisms and beyond. We propose new coarse-grained approaches to understand the underlying mechanisms of cell size control at the whole cell level.

PMID:
26901290
PMCID:
PMC5660915
DOI:
10.1016/j.ceb.2016.02.004
[Indexed for MEDLINE]
Free PMC Article

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