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PLoS One. 2016 Feb 22;11(2):e0149216. doi: 10.1371/journal.pone.0149216. eCollection 2016.

Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds.

Author information

1
Irkutsk State University, Institute of Biology, Irkutsk, Russia.
2
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany.
3
Universit├Ąt des Saarlandes-Pharmazeutische Biotechnologie, Saarbrucken, Germany.

Abstract

Actinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.

PMID:
26901168
PMCID:
PMC4764329
DOI:
10.1371/journal.pone.0149216
[Indexed for MEDLINE]
Free PMC Article

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