Format

Send to

Choose Destination
Cell Cycle. 2016;15(6):781-6. doi: 10.1080/15384101.2016.1151581.

4E-BP1, a multifactor regulated multifunctional protein.

Author information

1
a Department of Oncology , Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.

Abstract

Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-dependent translation to proceed. Recently, 4E-BP1 was shown to be phosphorylated by other kinases besides mTOR, and overexpression of 4E-BP1 was found in different human carcinomas. In this review, we summarize the novel findings on mTOR independent 4E-BP1 phosphorylation in carcinomas. The implications of overexpression and possible multi-function of 4E-BP1 are also discussed.

KEYWORDS:

cancer; eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1; kinase; mTOR; overexpression; phosphorylation

Comment in

PMID:
26901143
PMCID:
PMC4845917
DOI:
10.1080/15384101.2016.1151581
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center