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Nutr Metab (Lond). 2016 Feb 20;13:14. doi: 10.1186/s12986-016-0067-0. eCollection 2016.

Probiotics in prevention and treatment of obesity: a critical view.

Author information

1
Division of Endocrinology and Metabolic Diseases, Catholic University of Sacred Heart, A. Gemelli Medical School, Rome, Italy.
2
Division of Internal Medicine and Gastroenterology, Catholic University of Sacred Heart, A. Gemelli Medical School, Rome, Italy.
3
Department of Psychology, The University of Texas at Austin, Austin, TX USA ; University of Texas Imaging Research Center, Austin, TX USA.
4
Institute of Geotechnics, Department of Biotechnology, Slovak Academy of Sciences, Kosice, Slovak Republic.
5
2nd Department of Internal Medicine, Comenius University and University Hospital, Mickiewiczova 13, 813 69 Bratislava, Slovak Republic.
6
Faculty of Health Studies, University of Pardubice, Pardubice, Czech Republic.
7
Department of Gastroenterology, Central University Hospital of Asturias (HUCA), Oviedo, Spain.
8
Department of Gastroenterology, Central University Hospital of Asturias (HUCA), Oviedo, Spain ; 2nd Department of Internal Medicine, Faculty of Medicine, Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic ; Laboratory of Structural Biology and Proteomics, Central Laboratories, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.

Abstract

The worldwide prevalence of obesity more than doubled between 1980 and 2014. The obesity pandemic is tightly linked to an increase in energy availability, sedentariness and greater control of ambient temperature that have paralleled the socioeconomic development of the past decades. The most frequent cause which leads to the obesity development is a dysbalance between energy intake and energy expenditure. The gut microbiota as an environmental factor which influence whole-body metabolism by affecting energy balance but also inflammation and gut barrier function, integrate peripheral and central food intake regulatory signals and thereby increase body weight. Probiotics have physiologic functions that contribute to the health of gut microbiota, can affect food intake and appetite, body weight and composition and metabolic functions through gastrointestinal pathways and modulation of the gut bacterial community.

KEYWORDS:

Gut microbiota; Intestinal microflora; Obesity; Prevention; Probiotics; Treatment

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