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J Neurooncol. 2016 May;128(1):9-19. doi: 10.1007/s11060-016-2076-2. Epub 2016 Feb 22.

Pro-apoptotic and anti-angiogenic properties of the α /β-thujone fraction from Thuja occidentalis on glioblastoma cells.

Author information

1
Laboratorio de Patología Molecular, Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Campus Isla Teja s/n, P.O. Box 567, Valdivia, Chile.
2
Departamento de Patología del Hospital Base de Valdivia (HBV), Valdivia, Chile.
3
Laboratorio de Patología Molecular, Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Campus Isla Teja s/n, P.O. Box 567, Valdivia, Chile. claudiaquezada@uach.cl.

Abstract

The most aggressive type of brain tumor is glioblastoma multiforme, which to date remains incurable. Thuja occidentalis is used in homeopathy for the treatment of cancer, however, its mechanism of action remains unknown. We set out to study the effects of thujone fractions of Thuja on glioblastoma using in vitro and in vivo models. We found that the α/ β-thujone fraction decrease the cell viability and exhibit a potent anti-proliferative, pro-apoptotic and anti-angiogenic effects in vitro. In vivo assays showed that α /β-thujone promotes the regression of neoplasia and inhibits the angiogenic markers VEGF, Ang-4 and CD31 into the tumor.

KEYWORDS:

Angiogenesis; Angiopoietin-4; Apoptosis; Glioblastoma multiforme; Thuja occidentalis; α / β-Thujone fraction

PMID:
26900077
DOI:
10.1007/s11060-016-2076-2
[Indexed for MEDLINE]

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