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Bull Exp Biol Med. 2016 Feb;160(4):425-8. doi: 10.1007/s10517-016-3187-7. Epub 2016 Feb 22.

Effects of Millimeter-Wave Electromagnetic Radiation on the Experimental Model of Migraine.

Author information

1
Laboratory of Corticovisceral Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Moscow, Russia.
2
Laboratory of Restorative Treatment and Rehabilitation, St. Petersburg Institute of Bioregulation and Gerontology, North-West Division of the Russian Academy of Medical Sciences, Moscow, Russia.
3
Laboratory of Experimental Pharmacology of Cephalagias, A. V. Valdman Institute of Pharmacology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
4
Laboratory of Corticovisceral Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Moscow, Russia. olga@kolt.infran.ru.
5
Laboratory of Experimental Pharmacology of Cephalagias, A. V. Valdman Institute of Pharmacology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia. olga@kolt.infran.ru.

Abstract

Effects of millimeter-wave electromagnetic radiation (40 GHz frequency, 0.01 mW power) on the spontaneous fi ring of convergent neurons of the spinal trigeminal nucleus and their responses to electrical stimulation of the dura mater were studied in neurophysiological experiments on rats. Irradiation of the area of cutaneous receptive fields of spinal trigeminal nucleus reversibly inhibited both spontaneous discharges and activity induced by electrical stimulation of the dura mater. The second and third exposures to electromagnetic radiation with an interval of 10 min were ineffective. These results suggest that suppression of neuronal excitability in the spinal trigeminal ganglion can be a mechanism of the anti-migraine effects of electromagnetic radiation observed in clinical practice.

KEYWORDS:

migraine; millimeter-wave electromagnetic radiation; neuronal activity; spinal trigeminal nucleus

PMID:
26899844
DOI:
10.1007/s10517-016-3187-7
[Indexed for MEDLINE]

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