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J Infect Chemother. 2016 Aug;22(8):577-9. doi: 10.1016/j.jiac.2016.01.015. Epub 2016 Feb 16.

Multi-azole resistant Aspergillus fumigatus harboring Cyp51A TR46/Y121F/T289A isolated in Japan.

Author information

1
Division of Clinical Research, Medical Mycology Research Center, Chiba University, Japan.
2
Division of Bio-resources, Medical Mycology Research Center, Chiba University, Japan.
3
Department of Internal Medicine, Mitsui Memorial Hospital, Japan.
4
Department of Infection Control and Prevention, The University of Tokyo Hospital, Japan.
5
Department of Infection Control and Prevention, Mitsui Memorial Hospital, Japan.
6
Division of Clinical Research, Medical Mycology Research Center, Chiba University, Japan. Electronic address: fewata@faculty.chiba-u.jp.

Abstract

Multi-azole resistant Aspergillus fumigatus carrying TR46/Y121F/T289A was isolated from a patient in Japan in Dec 2013. This strain grouped into the same clade of the ones which were clinically isolated in France and Germany. A. fumigatus harboring this mutation could be rapidly diffused outside the Eurasian continent.

KEYWORDS:

Aspergillus fumigatus; Cyp51A; Multiple-antifungal resistance

PMID:
26898666
DOI:
10.1016/j.jiac.2016.01.015
[Indexed for MEDLINE]

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