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Dig Dis Sci. 2016 May;61(5):1268-81. doi: 10.1007/s10620-016-4045-1. Epub 2016 Feb 22.

Gut Microbiota of Nonalcoholic Fatty Liver Disease.

Author information

1
Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA. rabdou@upa.chob.edu.
2
Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA.
3
, 3435 Main Street, 413 Biomedical Research Building, Buffalo, NY, 14214, USA.

Abstract

The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microbiota.

KEYWORDS:

Fibrosis; Inflammation; Microbiota and intestinal permeability; NAFLD; NASH; Steatosis

PMID:
26898658
DOI:
10.1007/s10620-016-4045-1
[Indexed for MEDLINE]

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