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Clin Gastroenterol Hepatol. 2016 Jul;14(7):1056-9. doi: 10.1016/j.cgh.2016.01.021. Epub 2016 Feb 17.

Sessile Serrated Polyps are Precursors of Colon Carcinomas With Deficient DNA Mismatch Repair.

Author information

1
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
2
Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota.
3
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota. Electronic address: sinicrope.frank@mayo.edu.

Abstract

We investigated whether sessile serrated adenomas/polyps (SSA/Ps) are direct precursors of colorectal carcinomas. We identified colon carcinomas that arose from SSA/Ps among 2646 colorectal cancers included in the surgical pathology database at the Mayo Clinic (2006-2012). Molecular features of the serrated neoplasia pathway were analyzed in these tumors by immunohistochemical analyses of mutant BRAF (V600E) and MLH1 proteins. Among the 33 identified SSA/P-associated colonic adenocarcinomas (median patient age, 75 y), 24 developed in women (73%), 31 were located in the proximal colon (94%), and 23 (69%) were TNM stage I or II. Thirty-one of the tumors (94%) expressed mutant BRAF; of these, 26 also had loss of MLH1 (79%), indicating deficient DNA mismatch repair of sporadic origin. Twenty-two of the tumors (67%) were interval cancers that were more common in women and did not differ significantly in TNM stage, BRAF mutation, or loss of MLH1. By histopathology, SSA/Ps that were associated with colon carcinomas contained frequent dysplasia (48%). Most cancers that arose from SSA/Ps were located on the right side of the colon and had mutant BRAF and loss of MLH1. These findings indicate that SSA/Ps are precursors of most sporadic colon carcinomas with deficient DNA mismatch repair.

KEYWORDS:

Colon Cancer; Genetics; MMR; Progression

PMID:
26898652
PMCID:
PMC4912894
DOI:
10.1016/j.cgh.2016.01.021
[Indexed for MEDLINE]
Free PMC Article

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