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Macromol Biosci. 2016 Jun;16(6):896-905. doi: 10.1002/mabi.201500452. Epub 2016 Feb 22.

Solution Behavior of Amphiphilic Glycodendrimers with a Rod-Like Core.

Author information

1
Università degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, 20133, Milano, Italy.
2
Università degli Studi di Milano, Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Via Fratelli Cervi 93, 20090, Segrate, Milan, Italy.
3
Université Grenoble Alpes, IBS, F-38044, Grenoble, France.
4
CNRS, IBS, F-38044, Grenoble, France.
5
CEA, IBS, F-38044, Grenoble, France.
6
University of Ljubljana, Faculty of Chemistry and Chemical Technology, Večna pot 113, 1000, Ljubljana, Slovenia.

Abstract

Glycodendrimers based on aromatic cores have an amphiphilic character and have been reported to generate supramolecuar assemblies in water. A new group of glycodendrimers with an aromatic rod-like core were recently described as potent antagonists of DC-SIGN-mediated viral infections. A full characterization of the aggregation properties of these materials is presented here. The results show that these compounds exist mostly as monomers in water solution, in dynamic equilibrium with small aggregates (dimers or trimers). Larger aggregates observed by dynamic light scattering and transmission Electron Microscopy for some of the dendrimers are found to be portions of materials not fully solubilized and can be removed either by optimizing the dissolution protocol or by centrifugation of the samples.

KEYWORDS:

DC-SIGN; HIV; glycodendrimers; glycomimetics; morphological characterization

PMID:
26898184
DOI:
10.1002/mabi.201500452
[Indexed for MEDLINE]
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