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Trends Cell Biol. 2016 Apr;26(4):300-12. doi: 10.1016/j.tcb.2016.01.003. Epub 2016 Feb 16.

Probing the Complexities of Astrocyte Calcium Signaling.

Author information

1
Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.
2
Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
3
Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA; Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA. Electronic address: bkhakh@mednet.ucla.edu.

Abstract

Astrocytes are abundant glial cells that tile the entire central nervous system and mediate well-established functions for neurons, blood vessels, and other glia. These ubiquitous cells display intracellular Ca(2+) signals, which have been intensely studied for 25 years. Recently, the use of improved methods has unearthed the panoply of astrocyte Ca(2+) signals and a variable landscape of basal Ca(2+) levels. In vivo studies have started to reveal the settings under which astrocytes display behaviorally relevant Ca(2+) signaling. Studies in mice have emphasized how astrocyte Ca(2+) signaling is altered in distinct neurodegenerative diseases. Progress in the past few years, fueled by methodological advances, has thus reignited interest in astrocyte Ca(2+) signaling for brain function and dysfunction.

KEYWORDS:

AAV; GCaMP; astrocyte; calcium; imaging

PMID:
26896246
PMCID:
PMC4946798
DOI:
10.1016/j.tcb.2016.01.003
[Indexed for MEDLINE]
Free PMC Article
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