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Adv Ther. 2016 Mar;33(3):357-68. doi: 10.1007/s12325-016-0298-5. Epub 2016 Feb 19.

Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review.

Author information

1
Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal.
2
Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic.
3
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
4
Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
5
Southern California Permanente Medical Group, Woodland Hills, CA, USA.
6
Oral and Maxillofacial Pathology, School of Dentistry, University of Liverpool and Cellular Pathology, Liverpool Clinical Laboratories, Liverpool, UK.
7
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
8
Department of Pathology, Allegiance Health, Jackson, MI, USA.
9
University Pathologists, Providence, RI, USA.
10
University Pathologists, Fall River, MA, USA.
11
Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
12
Department of Pathology, Beth Israel Medical Center, New York, NY, USA.
13
Fundación de Investigación e Innovación Biosanitaria del Principado de Asturias, Oviedo, Spain.
14
Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, Spain.
15
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
16
Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
17
Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
18
Department of Head and Neck Surgery, Head and Neck Oncology Program, St Luc University Hospital and King Albert II Cancer Institute, Brussels, Belgium.
19
Department of Otolaryngology-Head and Neck Surgery, Nottingham University Hospitals, Queens Medical Centre Campus, Nottingham, UK.
20
European Salivary Gland Society, Geneva, Switzerland.
21
Departments of Surgery and Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
22
Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
23
Otorhinolaryngology-Head and Neck Surgery and Department of Oncology, Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
24
Department of Otolaryngology-Head and Neck Surgery, Philipp University, Marburg, Germany.
25
Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
26
Division of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA.
27
Department of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ, USA.
28
Department of Head and Neck Surgery and Otorhinolaryngology, A. C. Camargo Cancer Center, São Paulo, Brazil.
29
Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
30
Department of Radiation Oncology, University of Florida, Gainesville, FL, USA.
31
Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ, USA.
32
Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
33
University of Udine School of Medicine, Udine, Italy.
34
Coordinator of the International Head and Neck Scientific Group, Padua, Italy. a.ferlito@uniud.it.

Abstract

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.

KEYWORDS:

Adenoid cystic carcinoma; Dedifferentiation; Fatal outcome; High-grade transformation; Local recurrence; Lymphatic metastasis; Neck dissection; Neoplasm recurrence; Salivary glands

PMID:
26895332
PMCID:
PMC4833802
DOI:
10.1007/s12325-016-0298-5
[Indexed for MEDLINE]
Free PMC Article

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