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Oncotarget. 2016 Mar 29;7(13):15901-14. doi: 10.18632/oncotarget.7431.

PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma.

Author information

1
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
2
Department of Pathology, Seoul National University Hospital Seoul, Korea.
3
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
4
Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea.
5
Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
6
Department of Otorhinolaryngology, Seoul National University Hospital, Seoul, South Korea.

Abstract

Virus-associated malignancies and sarcomatoid cancers correlate with high PD-L1 expression, however, underlying mechanisms remain controversial. We evaluated the correlation between PD-L1 expression and epithelial-mesenchymal transition (EMT) in head and neck squamous cell carcinomas (HNSCC).Tumor tissues from 50 patients with HNSCC were evaluated for PD-L1 by immunohistochemistry, which showed 32 (64.0%) were PD-L1 positive (PD-L1+). Interestingly, PD-L1 expression was significantly associated with EMT (P = 0.010), as assessed by low E-cadherin and high vimentin expression. The overall survival of PD-L1+ patients with EMT features was significantly worse than those without EMT features (P = 0.007). In an independent validation cohort (N = 91), as well as in HNSCC cases of The Cancer Genome Atlas (TCGA) and the Cancer Cell Line Encyclopedia, high PD-L1 expression was also associated with the high probability of an EMT signature, referred from the GEO dataset, GSE4824. Survival analysis confirmed PD-L1+/EMT+ patients had a poorer prognosis than PD-L1+/EMT- patients in the TCGA cohort. PD-L1 positivity can thus be divided into two categories according to the absence or presence of EMT. PD-L1 expression is also independently associated with EMT features in HNSCC.

KEYWORDS:

PD-L1; epithelial-mesenchymal transition; head and neck; p16; squamous

PMID:
26893364
PMCID:
PMC4941285
DOI:
10.18632/oncotarget.7431
[Indexed for MEDLINE]
Free PMC Article

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