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Neuropsychol Rehabil. 2018 Apr;28(3):352-368. doi: 10.1080/09602011.2016.1148619. Epub 2016 Feb 18.

Prophylaxis and remediation of anomia in the semantic and logopenic variants of primary progressive aphasia.

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a Center for Aphasia Research and Rehabilitation , Georgetown University Medical Center , Washington , DC , USA.
b Department of Neurology , Johns Hopkins University , Baltimore , MD , USA.


This study evaluated the efficacy of phonological and orthographic treatments for anomia in the semantic and logopenic variants of primary progressive aphasia (svPPA and lvPPA, respectively). Both treatments were administered for 6 months. The treatment stimuli consisted of nouns that were consistently named correctly at baseline (prophylaxis items) and/or nouns that were consistently named incorrectly at baseline (remediation items). Oral naming accuracy was measured for trained and untrained picture exemplars, as well as matched items from an untrained condition (UC). Written naming and scene description tasks were also conducted. For all tasks, the change in naming accuracy from baseline to 1 month post-treatment was compared between the UC and each treatment condition. These comparisons indicated that both treatments were effective in the remediation and prophylaxis of anomia in both variants. Furthermore, generalisation to untrained exemplars occurred in both subtypes, whereas item generalisation occurred in lvPPA, and task generalisation was present in svPPA.


Treatment; anomia; primary progressive aphasia

[Available on 2019-04-01]
[Indexed for MEDLINE]

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