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Sci Rep. 2016 Feb 19;6:21807. doi: 10.1038/srep21807.

Long-term High Fat Ketogenic Diet Promotes Renal Tumor Growth in a Rat Model of Tuberous Sclerosis.

Author information

  • 1Medical University of Silesia, School of Medicine in Katowice, Department of Physiology, Katowice, Poland.
  • 2Affective Cognitive Neuroscience Lab, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology Polish Academy of Sciences Krakow, Poland.
  • 3Medical University of Silesia, School of Medicine in Katowice, Department of Pharmacology, Katowice, Poland.
  • 4Laboratory of Molecular Biology, Faculty of Physiotherapy, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.
  • 5Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland.
  • 6Warwick Systems Biology Centre, University of Warwick, CV4 7AL, UK.
  • 7Department of Neurology and Epileptology, The Children's Memorial Health Institute, Warsaw, Poland.

Abstract

Nutritional imbalance underlies many disease processes but can be very beneficial in certain cases; for instance, the antiepileptic action of a high fat and low carbohydrate ketogenic diet. Besides this therapeutic feature it is not clear how this abundant fat supply may affect homeostasis, leading to side effects. A ketogenic diet is used as anti-seizure therapy i.a. in tuberous sclerosis patients, but its impact on concomitant tumor growth is not known. To examine this we have evaluated the growth of renal lesions in Eker rats (Tsc2+/-) subjected to a ketogenic diet for 4, 6 and 8 months. In spite of existing opinions about the anticancer actions of a ketogenic diet, we have shown that this anti-seizure therapy, especially in its long term usage, leads to excessive tumor growth. Prolonged feeding of a ketogenic diet promotes the growth of renal tumors by recruiting ERK1/2 and mTOR which are associated with the accumulation of oleic acid and the overproduction of growth hormone. Simultaneously, we observed that Nrf2, p53 and 8-oxoguanine glycosylase α dependent antitumor mechanisms were launched by the ketogenic diet. However, the pro-cancerous mechanisms finally took the ascendency by boosting tumor growth.

PMID:
26892894
PMCID:
PMC4759602
DOI:
10.1038/srep21807
[PubMed - indexed for MEDLINE]
Free PMC Article
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