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Environ Res. 2016 May;147:172-8. doi: 10.1016/j.envres.2016.02.006. Epub 2016 Feb 15.

Urinary bisphenol A concentrations positively associated with glycated hemoglobin and other indicators of diabetes in Canadian men.

Author information

1
School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
2
School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: ychen@uottawa.ca.

Abstract

BACKGROUND:

Bisphenol A (BPA), an endocrine disrupting chemical (EDC), may pose a risk to human health, including diabetes. However, epidemiological studies from the U.S., China and South Korea showed inconsistent results.

OBJECTIVE:

To examine the associations between BPA and indicators of diabetes in the general Canadian population.

METHODS:

The analysis was based on cross-sectional data from the Canadian Health Measures Survey (CHMS) Cycle 2 (2009-2011). We included 1915 participants with glycated hemoglobin (HbA1c) measurement and 2405 participants with serum glucose (SG) measurement aged 3-79 years, respectively. Multiple linear regression analyses were performed to model HbA1c and log-transformed SG levels associated with quartiles of urinary BPA concentrations controlling for potential confounders. Further, in adults (age≥18 years), logistic regression analysis was conducted to evaluate the association between BPA and physician-diagnosed diabetes mellitus (DM). Bootstrap weights were applied to all the analyses to account for the complex survey design.

RESULTS:

The geometric mean of urinary BPA was 1.21 (±0.05)µg/L. Overall, a positive association was observed between urinary BPA quartiles and HbA1c levels in men after controlling for potential confounders (P<0.05), but not in women and children. Similar patterns were found for the associations of BPA with log-transformed SG levels and doctor-diagnosed DM.

CONCLUSIONS:

Higher urinary BPA levels were associated with adverse glucose homeostasis in Canadian men, independent of major covariates. Prospective studies with longitudinal design are needed to further investigate the causality.

KEYWORDS:

Bisphenol A; Canada; Diabetes; Glycated hemoglobin; Serum glucose; Survey

PMID:
26890259
DOI:
10.1016/j.envres.2016.02.006
[Indexed for MEDLINE]

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