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J Parkinsons Dis. 2016;6(1):231-7. doi: 10.3233/JPD-150725.

Risk Factor Profile in Parkinson's Disease Subtype with REM Sleep Behavior Disorder.

Author information

1
Department of Neurology, McGill University, Montreal General Hospital, Montréal, Canada.
2
Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Hôpital Gui de Chauliac, INSERM U1061, Montpellier, F-34093 Cedex 5 France.
3
Mayo Center for Sleep Medicine, Departments of Medicine and Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
4
Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada.
5
Department of Neurology, Hôpital Gui de Chauliac, INSERM U1061, Montpellier, F-34093 Cedex 5 France.
6
Département de psychologie, Université du Québec à Montréal, Montréal, QC, Canada.

Abstract

BACKGROUND:

Numerous large-scale studies have found diverse risk factors for Parkinson's disease (PD), including caffeine non-use, non-smoking, head injury, pesticide exposure, and family history. These studies assessed risk factors for PD overall; however, PD is a heterogeneous condition. One of the strongest identifiers of prognosis and disease subtype is the co-occurrence of rapid eye movement sleep behavior disorder (RBD).In previous studies, idiopathic RBD was associated with a different risk factor profile from PD and dementia with Lewy bodies, suggesting that the PD-RBD subtype may also have a different risk factor profile.

OBJECTIVE:

To define risk factors for PD in patients with or without associated RBD.

METHODS:

In a questionnaire, we assessed risk factors for PD, including demographic, medical, environmental, and lifestyle variables of 189 PD patients with or without associated polysomnography-confirmed RBD. The risk profile of patients with vs. without RBD was assessed with logistic regression, adjusting for age, sex, and disease duration.

RESULTS:

PD-RBD patients were more likely to have been a welder (OR = 3.11 (1.05-9.223), and to have been regular smokers (OR = 1.96 (1.04-3.68)). There were no differences in use of caffeine or alcohol, other occupations, pesticide exposure, rural living, or well water use. Patients with RBD had a higher prevalence of the combined family history of both dementia and parkinsonism (13.3% vs. 5.5% , OR = 3.28 (1.07-10.0).

CONCLUSION:

The RBD-specific subtype of PD may also have a different risk factor profile.

KEYWORDS:

Parkinson’s disease; REM sleep behavior disorder; risk factors

PMID:
26889635
DOI:
10.3233/JPD-150725
[Indexed for MEDLINE]

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