Format

Send to

Choose Destination
J Virol. 2016 Apr 14;90(9):4262-4268. doi: 10.1128/JVI.01980-15. Print 2016 May.

Emerging Roles of Protein Deamidation in Innate Immune Signaling.

Author information

1
Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA.
2
Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California, USA pinghui.feng@med.usc.edu.

Abstract

Protein deamidation has been considered a nonenzymatic process associated with protein functional decay or "aging." Recent studies implicate protein deamidation in regulating signal transduction in fundamental biological processes, such as innate immune responses. Work investigating gammaherpesviruses and bacterial pathogens indicates that microbial pathogens deploy deamidases or enzyme-deficient homologues (pseudoenzymes) to induce deamidation of key signaling components and evade host immune responses. Here, we review studies on protein deamidation in innate immune signaling and present several imminent questions concerning the roles of protein deamidation in infection and immunity.

PMID:
26889032
PMCID:
PMC4836359
DOI:
10.1128/JVI.01980-15
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center