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J Int Neuropsychol Soc. 2016 Feb;22(2):105-19. doi: 10.1017/S1355617716000060.

Modern Methods for Interrogating the Human Connectome.

Author information

1
1Imaging Institute,Cleveland Clinic,Cleveland,Ohio.
2
2The Mind Research Network,Albuquerque,New Mexico.
3
4Department of Psychiatry,University of Cambridge,Cambridge,United Kingdom.
4
5Neurological Institute,Cleveland Clinic,Cleveland,Ohio.

Abstract

OBJECTIVES:

Connectionist theories of brain function took hold with the seminal contributions of Norman Geschwind a half century ago. Modern neuroimaging techniques have expanded the scientific interest in the study of brain connectivity to include the intact as well as disordered brain.

METHODS:

In this review, we describe the most common techniques used to measure functional and structural connectivity, including resting state functional MRI, diffusion MRI, and electroencephalography and magnetoencephalography coherence. We also review the most common analytical approaches used for examining brain interconnectivity associated with these various imaging methods.

RESULTS:

This review presents a critical analysis of the assumptions, as well as methodological limitations, of each imaging and analysis approach.

CONCLUSIONS:

The overall goal of this review is to provide the reader with an introduction to evaluating the scientific methods underlying investigations that probe the human connectome.

KEYWORDS:

Complex network analysis; Diffusion MRI; EEG/MEG coherence; Human connectome; Independent components analysis; Resting state fMRI

PMID:
26888611
PMCID:
PMC4827018
DOI:
10.1017/S1355617716000060
[Indexed for MEDLINE]
Free PMC Article

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