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Br Med Bull. 2016 Mar;117(1):69-78. doi: 10.1093/bmb/ldw002. Epub 2016 Feb 16.

Human uterus transplantation in focus.

Author information

1
Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden.
2
Department of Obstetrics and Gynecology, La Fe University Hospital, University of Valencia, 46026 Valencia, Spain.
3
Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden Stockholm IVF, 12063 Stockholm, Sweden mats.brannstrom@obgyn.gu.se.

Abstract

INTRODUCTION:

Uterus transplantation (UTx) is introduced as the first treatment for absolute uterine factor infertility (AUFI), affecting 1:500 fertile aged women. This review presents potential patients, research and human UTx cases.

SOURCES OF DATA:

Published articles and our research experience.

AREAS OF AGREEMENT:

The first UTx live births in 2014 established UTx as a possible treatment for AUFI. This was proceeded by 15 years of systematic research.

AREAS OF CONTROVERSY:

Is a deceased donor UTx as effective as the proven successful live donor UTx?.

GROWING POINTS:

Human UTx trials will accumulate data on risks, effectiveness and long-term consequences for donors, recipients and children. These should also include aspects of quality of life, psychological well-being and cognitive/neuropsychiatric development of children.

AREAS TIMELY FOR DEVELOPING RESEARCH:

All new activities in human UTx within the coming years should be conducted as prospective observational studies, and data should also be collected within an international registry.

KEYWORDS:

infertility; transplantation; uterus

PMID:
26888381
DOI:
10.1093/bmb/ldw002
[Indexed for MEDLINE]

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