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Immunotherapy. 2016 May;8(5):527-40. doi: 10.2217/imt-2016-0007. Epub 2016 Feb 18.

Clinical relevance of antigen spreading pattern induced by CHP-MAGE-A4 cancer vaccination.

Author information

1
Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
2
Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Abstract

AIM:

To investigate the antigen spreading pattern in the CHP-MAGE-A4-vaccinated patients and analyze the clinical relevance of antigen spreading pattern as a surrogate marker of patient survival.

MATERIALS & METHODS:

12 patients who had been injected with 300 μg of CHP-MAGE-A4 and 0.5 Klinische Einheit of OK-432 in more than five vaccinations were analyzed.

RESULTS:

Increases in the anti-MAGE-A4-specific antibody response were observed in eight patients (66.7%), compared with six patients (50%) for anti-NY-ESO-1 and five patients (41.7%) for anti-MAGE-A3 after five vaccinations. We identified frequent antigen spreading following MAGE-A4 vaccinations without associations with the clinical response or patient prognosis.

CONCLUSION:

Antigen spreading pattern might reflect tumor shrinkage as a response to treatment and treatment history (clinical trial registration number: UMIN000001999).

KEYWORDS:

IgG subtypes; MAGE-A4; antigen spreading; cancer vaccine; immunomonitoring

PMID:
26888315
DOI:
10.2217/imt-2016-0007
[Indexed for MEDLINE]

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