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Magn Reson Med. 2017 Feb;77(2):779-786. doi: 10.1002/mrm.26141. Epub 2016 Feb 17.

Accelerating chemical exchange saturation transfer (CEST) MRI by combining compressed sensing and sensitivity encoding techniques.

Author information

1
Divison of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
2
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.

Abstract

PURPOSE:

To evaluate the feasibility of accelerated chemical-exchange-saturation-transfer (CEST) imaging using a combination of compressed sensing (CS) and sensitivity encoding (SENSE) at 3 Tesla.

THEORY AND METHODS:

Two healthy volunteers and six high-grade glioma patients were recruited. Raw CEST image k-space data were acquired (with varied radiofrequency saturation power levels for the healthy volunteer study), and a sequential CS and SENSE reconstruction (CS-SENSE) was assessed. The MTRasym (3.5 ppm) signals were compared with varied CS-SENSE acceleration factors.

RESULTS:

In the healthy volunteer study, a CS-SENSE acceleration factor of R = 2 × 2 (CS × SENSE) was achieved without compromising the reconstructed MTRasym (3.5 ppm) image quality. The MTRasym (3.5 ppm) signals obtained from the CS-SENSE reconstruction with R = 2 × 2 were well preserved compared with the reference image (R = 2 for only SENSE). In the glioma patient study, the MTRasym (3.5 ppm) signals were significantly higher in the tumor region (Gd-enhancing tumor core) than in the normal-appearing white matter (P < 0.001). There was no significant MTRasym (3.5 ppm) difference between the reference image and CS-SENSE-reconstructed image in the acceleration factor of R = 2 × 2.

CONCLUSION:

Combining the SENSE technique with CS (R = 2 × 2) enables considerable acceleration of CEST image acquisition and potentially has a wide range of clinical applications. Magn Reson Med 77:779-786, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

KEYWORDS:

APT; CEST; SENSE; brain tumor; compressed sensing

PMID:
26888295
PMCID:
PMC4988943
DOI:
10.1002/mrm.26141
[Indexed for MEDLINE]
Free PMC Article

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