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Pediatr Crit Care Med. 2016 Apr;17(4):e193-7. doi: 10.1097/PCC.0000000000000644.

Micro-RNA-208a, -208b, and -499 as Biomarkers for Myocardial Damage After Cardiac Surgery in Children.

Author information

1
1Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 2Department of Pediatrics, Sackler Medical School, Tel-Aviv University, Tel-Aviv, Israel.

Abstract

OBJECTIVES:

To test the hypothesis that cardiac-enriched micro-RNAs can serve as accurate biomarkers that reflect myocardial injury and to predict the postoperative course following pediatric cardiac surgery. Micro-RNAs have emerged as plasma biomarkers for many pathologic states. We aimed to quantify preoperative and postoperative plasma levels of cardiac-enriched micro-RNA-208a, -208b, and -499 in children undergoing cardiac surgery and to evaluate correlations between their levels, the extent of myocardial damage, and the postoperative clinical course.

DESIGN:

PICU.

PATIENTS:

Thirty pediatric patients that underwent open heart surgery for the correction of congenital heart defects between January 2012 to July 2013.

INTERVENTIONS:

None.

MEASUREMENTS AND MAIN RESULTS:

At 12 hours post surgery, the plasma levels of the micro-RNAs increased by 300- to 4,000-fold. At 24 hours, their levels decreased but remained significantly higher than before surgery. Micro-RNA levels were associated with troponin levels, longer cardiopulmonary bypass and aortic crossclamp times, maximal postoperative aspartate aminotransferase levels, and delayed hospital discharge.

CONCLUSIONS:

Circulating micro-RNA-208a, -208b, and -499 are detectable in the plasma of children undergoing cardiac surgery and may serve as novel biomarkers for monitoring and forecasting postoperative myocardial injury and recovery.

PMID:
26886516
DOI:
10.1097/PCC.0000000000000644
[Indexed for MEDLINE]

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