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Redox Rep. 2016 Nov;21(6):248-53. doi: 10.1080/13510002.2015.1116729. Epub 2016 Feb 18.

Increased oxidative stress in children with attention deficit hyperactivity disorder.

Author information

1
a Department of Clinical Biochemistry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
2
b Department of Child and Adolescent Psychiatry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
3
c Department of Psychiatry , Balikligol State Hospital , Sanliurfa , Turkey.

Abstract

OBJECTIVES:

The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD).

METHODS:

Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls).

RESULTS:

Age and sex were similar between the groups (P > 0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P < 0.001). PON-1 (P = 0.002), ARE (P = 0.010) activity and TAS (P < 0.001) were lower in the patient group than the control group.

DISCUSSION:

We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD.

KEYWORDS:

Arylesterase; Attention deficit hyperactivity disorder; Oxidative stress; Paraxonase-1

PMID:
26886057
DOI:
10.1080/13510002.2015.1116729
[Indexed for MEDLINE]

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