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Antimicrob Agents Chemother. 2016 Apr 22;60(5):3138-40. doi: 10.1128/AAC.02961-15. Print 2016 May.

Susceptibility of Multidrug-Resistant Gram-Negative Urine Isolates to Oral Antibiotics.

Author information

1
Northeastern University, Boston, Massachusetts, USA Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA e.hirsch@neu.edu.
2
Northeastern University, Boston, Massachusetts, USA.
3
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA Harvard Medical School, Boston, Massachusetts, USA.
4
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Abstract

Increasing resistance among Gram-negative uropathogens limits treatment options, and susceptibility data for multidrug-resistant isolates are limited. We assessed the activity of five oral agents against 91 multidrug-resistant Gram-negative urine isolates that were collected from emergency department/hospitalized patients. Fosfomycin and nitrofurantoin were most active (>75% susceptibility). Susceptibilities to sulfamethoxazole-trimethoprim, ciprofloxacin, and ampicillin were ≤40%; empirical use of these agents likely provides inadequate coverage in areas with a high prevalence of multidrug-resistant uropathogens.

PMID:
26883704
PMCID:
PMC4862536
DOI:
10.1128/AAC.02961-15
[Indexed for MEDLINE]
Free PMC Article

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