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J Diabetes Res. 2016;2016:6789402. doi: 10.1155/2016/6789402. Epub 2016 Jan 5.

The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio.

Author information

1
Geriatrics Department, The First Hospital of China Medical University, Shenyang, Liaoning, China.
2
Endocrine Department, The First Hospital of China Medical University, Shenyang, Liaoning, China.
3
Endocrine Department, The People Hospital of Liaoning Province, Shenyang, Liaoning, China.

Abstract

OBJECTIVE:

To investigate the expression of miR-192 and its significance in diabetic nephropathy (DN) patients.

METHODS:

464 patients with type 2 diabetes mellitus (T2DM) were divided into normal albuminuria group (NA, n = 157), microalbuminuria group (MA, n = 159), and large amount of albuminuria group (LA, n = 148). 127 healthy persons were selected as the control group (NC, n = 127). The serum miR-192 levels were detected by Real-Time PCR and transforming growth factor-β1 (TGF-β1) and fibronectin (FN) were detected by enzyme-linked immunosorbent assay. The relationships among these parameters were analyzed by Pearson correlation analysis and multiple linear regression analysis.

RESULTS:

The miR-192 in the LA group was significantly lower than other groups, which was lower in the MA group than in the NA group (P < 0.01). The TGF-β1 and FN in the LA group were significantly higher than other groups, which were higher in the MA group than in the NA group (P < 0.01). The expression of miR-192 was negatively correlated with TGF-β1, FN, and Ln (UACR) and miR-192, TGF-β1, and FN were independent relevant factors affecting Ln (UACR) in T2DM (P < 0.01).

CONCLUSIONS:

These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.

PMID:
26881255
PMCID:
PMC4736386
DOI:
10.1155/2016/6789402
[Indexed for MEDLINE]
Free PMC Article

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