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Oxid Med Cell Longev. 2016;2016:8378613. doi: 10.1155/2016/8378613. Epub 2016 Jan 6.

A Potential Alternative against Neurodegenerative Diseases: Phytodrugs.

Author information

1
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, 06726 México, DF, Mexico; Posgrado en Biología Experimental, Universidad Autónoma Metropolitana-Iztapalapa, 09340 México, DF, Mexico.
2
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, 06726 México, DF, Mexico; Programa de Becas Posdoctorales, Universidad Nacional Autónoma de México, 04510 México, DF, Mexico.
3
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, 06726 México, DF, Mexico; Posgrado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, 04510 México, DF, Mexico.
4
División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, 09340 México, DF, Mexico.
5
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, 06726 México, DF, Mexico.

Abstract

Neurodegenerative diseases (ND) primarily affect the neurons in the human brain secondary to oxidative stress and neuroinflammation. ND are more common and have a disproportionate impact on countries with longer life expectancies and represent the fourth highest source of overall disease burden in the high-income countries. A large majority of the medicinal plant compounds, such as polyphenols, alkaloids, and terpenes, have therapeutic properties. Polyphenols are the most common active compounds in herbs and vegetables consumed by man. The biological bioactivity of polyphenols against neurodegeneration is mainly due to its antioxidant, anti-inflammatory, and antiamyloidogenic effects. Multiple scientific studies support the use of herbal medicine in the treatment of ND; however, relevant aspects are still pending to explore such as metabolic analysis, pharmacokinetics, and brain bioavailability.

PMID:
26881043
PMCID:
PMC4736801
DOI:
10.1155/2016/8378613
[Indexed for MEDLINE]
Free PMC Article

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