Format

Send to

Choose Destination
Tumour Biol. 2016 May;37(5):5751-60. doi: 10.1007/s13277-016-4966-5. Epub 2016 Feb 15.

Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers.

He S1,2, Zhong Y1,2, Shuai C3, Gao D1,2, Wei P1,2, Li G1,2, Peng S4,5.

Author information

1
Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.
2
Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, China.
3
Orthopedic Biomedical Materials Institute, Central South University, Changsha, 410083, China.
4
Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China. shuping@csu.edu.cn.
5
Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, 410078, China. shuping@csu.edu.cn.

Abstract

Nasopharyngeal carcinoma-associated gene 6 (NGX6) is a membrane protein primarily located in the nuclear membrane and cell membrane. Several groups reported that NGX6 gene was down-regulated in nasopharyngeal carcinoma (NPC), gastric cancer, lung cancer, liver cancer, and colorectal cancer and even less in the carcinomas with metastasis. Current studies have demonstrated that NGX6 possesses various biological functions, such as regulating protein expression of related genes, involving cell signal transduction pathways, negatively controlling cell cycle progression, inhibiting angiogenesis, and increasing the sensitivity of patients to anti-cancer drugs. Some factors regulating the expression level of NGX6 gene also have been studied. The methylation of promoter of NGX6 and histone H3K9 negatively regulates its expression, similar to the function of transcription factor special protein-1 (Sp1). However, the regulatory factor early growth response gene 1 (Egr-1) is provided with positive regulation function. This review will summarize the progress of those studies on NGX6 and elucidate the potential application of NGX6 for some malignant diseases.

KEYWORDS:

Growth; Metastasis; NGX6; Tumor suppressor

PMID:
26880583
DOI:
10.1007/s13277-016-4966-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center