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Future Oncol. 2016 Mar;12(5):669-85. doi: 10.2217/fon.15.335. Epub 2016 Feb 1.

The role of neoadjuvant therapy in pancreatic cancer: a review.

Author information

1
Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.
2
Department of Surgery, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.
3
Department of Medicine, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.

Abstract

Controversy remains regarding neoadjuvant approaches in the treatment of pancreatic cancer. Neoadjuvant therapy has several potential advantages over adjuvant therapy including earlier delivery of systemic treatment, in vivo assessment of response, increased resectability rate in borderline resectable patients and increased margin-negative resection rate. At present, there are no randomized data favoring neoadjuvant over adjuvant therapy and multiple neoadjuvant approaches are under investigation. Combination chemotherapy regimens including 5-fluorouracil, irinotecan and oxaliplatin, gemcitabine with or without abraxane, or docetaxel and capecitabine have been used in the neoadjuvant setting. Radiation and chemoradiation have also been incorporated into neoadjuvant strategies, and delivery of alternative fractionation regimens is being explored. This review provides an overview of neoadjuvant therapies for pancreatic cancer.

KEYWORDS:

5-fluorouracil; abraxane; capecitabine; chemotherapy; docetaxel; gemcitabine; irinotecan; oxaliplatin; pancreatic cancer; radiation; surgery

PMID:
26880384
PMCID:
PMC5549642
DOI:
10.2217/fon.15.335
[Indexed for MEDLINE]
Free PMC Article

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