Format

Send to

Choose Destination
Lancet. 2016 Apr 23;387(10029):1785-8. doi: 10.1016/S0140-6736(15)00417-1. Epub 2016 Feb 12.

Averting a malaria disaster: will insecticide resistance derail malaria control?

Author information

1
Liverpool School of Tropical Medicine, Liverpool, UK. Electronic address: Janet.Hemingway@lstmed.ac.uk.
2
Liverpool School of Tropical Medicine, Liverpool, UK.
3
Bill & Melinda Gates Foundation, Seattle, WA, USA.
4
The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland.
5
President's Malaria Initiative, US Agency for International Development, Washington, DC, USA.
6
Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria, Atlanta, GA, USA.
7
Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
8
Maladies Infectieuses et Vecteurs: Ecologie, Genetique, Evolution et Contrôle (MIVEGEC), Université de Montpellier, Institut de Recherche pour le Développement, Montpellier, France.
9
Centre Muraz, Bobo Dioulasso, Burkina Faso.
10
National Malaria Control Program, N'Djaména, Chad.
11
Rothamsted Research, Harpenden, UK.
12
University of Oxford, Oxford, UK.
13
London School of Hygiene & Tropical Medicine, London, UK.
14
Insecticide Resistance Action Committee, Crop Life International AISBL, Brussels, Belgium.
15
Innovative Vector Control Consortium, Liverpool, UK.

Abstract

World Malaria Day 2015 highlighted the progress made in the development of new methods of prevention (vaccines and insecticides) and treatment (single dose drugs) of the disease. However, increasing drug and insecticide resistance threatens the successes made with existing methods. Insecticide resistance has decreased the efficacy of the most commonly used insecticide class of pyrethroids. This decreased efficacy has increased mosquito survival, which is a prelude to rising incidence of malaria and fatalities. Despite intensive research efforts, new insecticides will not reach the market for at least 5 years. Elimination of malaria is not possible without effective mosquito control. Therefore, to combat the threat of resistance, key stakeholders need to rapidly embrace a multifaceted approach including a reduction in the cost of bringing new resistance management methods to market and the streamlining of associated development, policy, and implementation pathways to counter this looming public health catastrophe.

PMID:
26880124
DOI:
10.1016/S0140-6736(15)00417-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center