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BMC Res Notes. 2016 Feb 15;9:95. doi: 10.1186/s13104-016-1922-9.

Normocellular CSF in herpes simplex encephalitis.

Author information

1
WHO-CC for Research and Training on Viral Zoonoses, Division of Neurology, Department of Medicine, Faculty of Medicine, Neuroscience Centre for Research and Development, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand. abhinbhen@gmail.com.
2
WHO-CC for Research and Training on Viral Zoonoses, Division of Neurology, Department of Medicine, Faculty of Medicine, Neuroscience Centre for Research and Development, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand. spwa@hotmail.com.
3
WHO-CC for Research and Training on Viral Zoonoses, Division of Neurology, Department of Medicine, Faculty of Medicine, Neuroscience Centre for Research and Development, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand. cakeinarak@hotmail.com.
4
WHO-CC for Research and Training on Viral Zoonoses, Division of Neurology, Department of Medicine, Faculty of Medicine, Neuroscience Centre for Research and Development, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand. n.sittidetboripat@gmail.com.
5
WHO-CC for Research and Training on Viral Zoonoses, Division of Neurology, Department of Medicine, Faculty of Medicine, Neuroscience Centre for Research and Development, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand. siriporn.ghai@gmail.com.
6
WHO-CC for Research and Training on Viral Zoonoses, Division of Neurology, Department of Medicine, Faculty of Medicine, Neuroscience Centre for Research and Development, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand. henrywilde27@gmail.com.
7
Division of Infectious Disease, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand. henrywilde27@gmail.com.
8
WHO-CC for Research and Training on Viral Zoonoses, Division of Neurology, Department of Medicine, Faculty of Medicine, Neuroscience Centre for Research and Development, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand. fmedthm@gmail.com.

Abstract

BACKGROUND:

Herpes simplex virus (HSV) is the most common cause of sporadic encephalitis worldwide. The high mortality rate (70-80 %) of herpes simplex encephalitis (HSE) can be reduced to 20-30 % by antiviral therapy. However, normocellular CSF can lure physicians to look for non-infectious causes, resulting in delayed treatment. This study aimed to investigate, characterize and differentiate HSE patients, with normocellular and pleocytosis CSF, according to neuroimaging patterns, underlying disease, CSF viral load and clinical outcome. Patients with proven (by PCR positive CSF) or presumed viral infections of the CNS admitted to King Chulalongkorn Memorial Hospital between January 2002 and 2011 were analyzed.

RESULTS:

HSV was detected in the CSF of 43 patients but only 23 patients had encephalitis. Among these 23 patients, 6 cases (26.1 %) had normal CSF WBC (<5 cells/mm(3)). One patient in this normocellular CSF group had HIV infection. Although this patient had low CD4 counts (<200 cells/mm(3)), the peripheral WBC counts showed only mild leukopenia. The CSF HSV viral load in the pleocytosis group was higher than the normocellular group, with an average of 12,200 vs 3027 copies/ml respectively. There was no correlation between the viral load and the clinical outcome. With respect to neuroimaging, 4 (66.7 %) patients in the normocellular group had unremarkable/non-specific results.

CONCLUSIONS:

Normocellular CSF in HSE is not rare, and can be seen in normal as well as immunocompromised hosts. Clinicians should not exclude CNS infection, especially HSE, merely based on the absence of CSF pleocytosis and/or unremarkable neuroimaging study.

PMID:
26879928
PMCID:
PMC4753680
DOI:
10.1186/s13104-016-1922-9
[Indexed for MEDLINE]
Free PMC Article

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