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Nat Neurosci. 2016 Apr;19(4):605-12. doi: 10.1038/nn.4251. Epub 2016 Feb 15.

4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.

Author information

1
INSERM, Neurocentre Magendie, U862, Bordeaux, France.
2
Univ. Bordeaux, Neurocentre Magendie, U862, Bordeaux, France.
3
Bernstein Center for Computational Neuroscience Munich, Munich Cluster of Systems Neurology (SyNergy), Faculty of Medicine, Ludwig-Maximilians Universität München, Planegg-Martinsried, Germany.
4
Team Memory, Oscillations and Brain states (MOBs), Brain Plasticity Unit, CNRS UMR 8249, ESPCI ParisTech, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Paris, France.
5
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

Abstract

Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological and optogenetic manipulations, we found that freezing, a behavioral expression of fear, temporally coincided with the development of sustained, internally generated 4-Hz oscillations in prefrontal-amygdala circuits. 4-Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4-Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behavior. These results unravel a sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behavior.

PMID:
26878674
PMCID:
PMC4843971
DOI:
10.1038/nn.4251
[Indexed for MEDLINE]
Free PMC Article

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