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Nat Neurosci. 2016 Apr;19(4):560-3. doi: 10.1038/nn.4245. Epub 2016 Feb 15.

Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons.

Author information

1
Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
2
Sorbonne Universités, Neuroscience Paris Seine, CNRS UMR 8246, INSERM U 1130, Université Pierre et Marie Curie, Paris, France.

Abstract

Dopamine (DA) neurons in the ventral tegmental area (VTA) help mediate stress susceptibility and resilience. However, upstream mechanisms controlling these neurons remain unknown. Noradrenergic (NE) neurons in the locus coeruleus, implicated in the pathophysiology of depression, have direct connections within the VTA. Here we demonstrate that NE neurons regulate vulnerability to social defeat through inhibitory control of VTA DA neurons.

PMID:
26878672
DOI:
10.1038/nn.4245
[Indexed for MEDLINE]

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