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Nat Neurosci. 2016 Apr;19(4):568-70. doi: 10.1038/nn.4249. Epub 2016 Feb 15.

An excitatory basis for divisive normalization in visual cortex.

Author information

1
UCL Institute of Ophthalmology, University College London, London, UK.
2
Wolfson Institute for Biomedical Research, University College London, London, UK.

Abstract

Neurons in visual cortex are connected not only locally, but also through networks of distal connectivity. These distal networks recruit both excitatory and inhibitory synapses and result in divisive normalization. Normalization is traditionally thought to result from increases in synaptic inhibition. By combining optogenetic stimulation and intracellular recordings in mouse visual cortex, we found that, on the contrary, normalization is a result of a decrease in synaptic excitation.

PMID:
26878671
PMCID:
PMC4817833
DOI:
10.1038/nn.4249
[Indexed for MEDLINE]
Free PMC Article

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