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Nat Chem Biol. 2016 Apr;12(4):215-7. doi: 10.1038/nchembio.2023. Epub 2016 Feb 15.

YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids.

Author information

1
School of Chemistry, University of Melbourne, Parkville, Victoria, Australia.
2
Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.
3
Department of Chemistry, University of York, Heslington, York, UK.
4
ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
5
Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.

Abstract

Sulfoquinovose is produced by photosynthetic organisms at a rate of 10(10) tons per annum and is degraded by bacteria as a source of carbon and sulfur. We have identified Escherichia coli YihQ as the first dedicated sulfoquinovosidase and the gateway enzyme to sulfoglycolytic pathways. Structural and mutagenesis studies unveiled the sequence signatures for binding the distinguishing sulfonate residue and revealed that sulfoquinovoside degradation is widespread across the tree of life.

PMID:
26878550
DOI:
10.1038/nchembio.2023
[Indexed for MEDLINE]

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