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World J Gastroenterol. 2016 Feb 14;22(6):2046-59. doi: 10.3748/wjg.v22.i6.2046.

Glucose metabolism in gastric cancer: The cutting-edge.

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Lian-Wen Yuan, Department of Geriatric Surgery, Second Xiangya Hospital, Center-South University, Changsha 410011, Hunan Province, China.


Glucose metabolism in gastric cancer cells differs from that of normal epithelial cells. Upregulated aerobic glycolysis (Warburg effect) in gastric cancer meeting the demands of cell proliferation is associated with genetic mutations, epigenetic modification and proteomic alteration. Understanding the mechanisms of aerobic glycolysis may contribute to our knowledge of gastric carcinogenesis. Metabolomic studies offer novel, convenient and practical tools in the search for new biomarkers for early detection, diagnosis, prognosis, and chemosensitivity prediction of gastric cancer. Interfering with the process of glycolysis in cancer cells may provide a new and promising therapeutic strategy for gastric cancer. In this article, we present a brief review of recent studies of glucose metabolism in gastric cancer, with primary focus on the clinical applications of new biomarkers and their potential therapeutic role in gastric cancer.


Biomarker; Gastric cancer; Glucose metabolism; Metabolomics; Therapy; Warburg effect

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